The role of Wnt signaling in cancer and stem cells.

  title={The role of Wnt signaling in cancer and stem cells.},
  author={Noem{\'i} Reguart and Biao He and M{\`i}quel Taron and Liang You and David Mark Jablons and Rafael Rosell},
  journal={Future oncology},
  volume={1 6},
The Wingless-Int (Wnt) signaling pathway has been widely investigated in recent years. Initially, its role regulating cell proliferation and survival during embryogenesis aroused the interest of researchers. Later, the focus was placed on the link between aberrant Wnt pathway activation and human cancer. The improper function of Wnt signaling components can lead to aberrant cell proliferation and cancer. Mutations in the adenomatous polyposis coli and beta-catenin genes first implicated Wnt… CONTINUE READING


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