The role of Wnt proteins in arthritis

  title={The role of Wnt proteins in arthritis},
  author={Georg Schett and Jochen Zwerina and J. David},
  journal={Nature Clinical Practice Rheumatology},
Wnt proteins regulate organ development, tumorigenesis and bone homeostasis, among other functions. The binding of Wnt proteins to plasma membrane receptors on mesenchymal cells induces the differentiation of these cells into the osteoblast lineage and thereby supports bone formation. Wnts are also key signaling proteins in joint remodeling processes. Active Wnt signaling contributes to osteophyte formation and might have an essential role in the anabolic pattern of joint remodeling that is… CONTINUE READING