The role of WT1 in oncogenesis: tumor suppressor or oncogene?

  title={The role of WT1 in oncogenesis: tumor suppressor or oncogene?},
  author={David Mark Loeb and Saraswati V. Sukumar},
  journal={International journal of hematology},
  volume={76 2},
Although originally identified as a tumor suppressor gene, WT1 is overexpressed in a variety of hematologic malignancies and solid tumors, including acute leukemia, breast cancer, malignant mesothelioma, renal cell carcinoma, and others. Overexpression of both wild-type and mutant WT1 has been reported. In some cases, this finding represents overexpression of a gene that should be expressed at lower levels, but in other cases, WT1 is expressed at high levels in a tissue type in which there is… CONTINUE READING
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