The role of VEGF-A in glomerular development and function

  title={The role of VEGF-A in glomerular development and function},
  author={Vera Eremina and Susan E. Quaggin},
  journal={Current Opinion in Nephrology and Hypertension},
  • V. Eremina, S. Quaggin
  • Published 1 January 2004
  • Biology, Medicine
  • Current Opinion in Nephrology and Hypertension
Purpose of reviewVascular endothelial growth factor is a major regulator of blood vessel biology and is highly expressed in presumptive and mature podocytes within the glomerulus. It has long been recognized that dysregulation of this factor occurs in a number of glomerular diseases; however, definitive proof that it plays a pathogenic or developmental role in glomerular biology has remained elusive. This review will summarize some of the recent advances in our understanding of the role(s) of… 

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It is shown that tubulovascular cross-talk by Vegfa is essential for maintenance of peritubular capillary networks in kidney, and disruption of this communication leads to increased renal Epo production and resulting polycythemia, presumably to counterbalance microvascular losses.

Do kidney tubules serve an angiogenic soup?

  • A. Woolf
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  • 2004
It is noted that, in several models of renal disease, the integrity of peritubular capillaries has a positive correlation with renal function; furthermore, in the rat remnant kidney, tubular VEGF-A becomes diminished, and the administration of VEGf-A minimizes loss of per itubularcapillaries and stabilizes renal function.

Role of the Mammalian Target of Rapamycin (mTOR) Signalling Pathway in Podocytes in Glomerular Disease

The aim of this chapter is to summarize the current research on the contribution of podocytes to the disease process in glomerulonephritis in connection to the mTOR signaling pathway.

Expression of pigment-epithelium-derived factor during kidney development and aging

The results are the first to suggest that PEDF is important in early renal postnatal development, that it could be relevant to the maturation of glomerular function and the filtration barrier formed by these cells, and that it may serve as an anti-angiogenic modulator during kidney development.

Crim1 Mice Implicate Crim1 in the Regulation of Vascular Endothelial Growth Factor-A Activity during Glomerular Vascular Development

This is the first in vivo demonstration of regulation of VEGF-A delivery and supports the hypothesis that Crim1 functions to regulate the release of growth factors from the cell of synthesis.

Effects of increased renal tubular vascular endothelial growth factor (VEGF) on fibrosis, cyst formation, and glomerular disease.

This study shows that systemic VEGF interferes with the intraglomerular cross-talk between podocytes and the endocapillary compartment, leading to severe deterioration in glomerular architecture, similar to that seen in diabetic nephropathy.

Autocrine VEGF-VEGF-R loop on podocytes during glomerulonephritis in humans.

  • B. HohensteinM. Colin C. Hugo
  • Biology, Medicine
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
  • 2010
This study shows, for the first time, increased podocytic VEGF-VEGF-R binding during human GN, suggesting not only the existence of a glomerular paracrine proangiogenic, but also an autocrine role of the VEGf-VE GF-R system in diseased podocytes.

Role of the SDF-1/CXCR4/eNOS Signaling Pathway in Chronic Kidney Disease

Observations indicate that local eNOSdependent SDF-1/CXCR4 signaling exerts a compensatory reno-protective effect in the renal microvasculature in patients with secondary focal segmental glomerulosclerosis.



Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases.

The data demonstrate that tight regulation of VEGF-A signaling is critical for establishment and maintenance of the glomerular filtration barrier and strongly supports a pivotal role for VEGf-A in renal disease.

Angiopoietins: microvascular modulators with potential roles in glomerular pathophysiology.

Understanding of the regulation of the filtration barrier is incomplete but the expression of angiopoietins in the glomerulus suggests a mechanism for maintenance of the glomersular endothelium and modulation of the actions of glomerular VEGF.

Vascular endothelial growth factor is an essential molecule for mouse kidney development: glomerulogenesis and nephrogenesis.

VEGF is likely to be an essential molecule for kidney development, and especially for glomerulogenesis, by blocking the endogenous VEGF activity with antibody in newborn mice.

Impaired angiogenesis in the remnant kidney model: I. Potential role of vascular endothelial growth factor and thrombospondin-1.

Impaired angiogenesis characterizes the remnant kidney model and is correlated with progression, and may be mediated by alterations in the renal expression of TSP-1 and VEGF, with the latter being regulated by macrophage-associated cytokines.

Loss of the VEGF(164) and VEGF(188) isoforms impairs postnatal glomerular angiogenesis and renal arteriogenesis in mice.

In VEGF(120/120) mice, ingrowth and survival of capillaries in glomeruli, remodeling of peritubularcapillaries, vascular coverage by pericytes, and branching of renal arteries were all severely impaired, causing abnormal glomerular filtration and impairing renal function.

Expression of neuropilin-1 by human glomerular epithelial cells in vitro and in vivo.

The present study suggests that vGECs may have the potential to bind the VEGF that they secrete, and functional studies will be required to address the potential significance of this finding in terms of an autocrine loop or V EGF sequestration.

Downregulation of Vascular Endothelial Growth Factor and Its Receptors in the Kidney in Rats with Puromycin Aminonucleoside Nephrosis

The results indicate that the VEGF-VEGF receptor system is downregulated in PAN, implying that it is not involved in the mechanism of proteinuria in PAN.

Glomerular endothelial cells are maintained by vascular endothelial growth factor in the adult kidney.

Demand for VEGF signaling in the glomerulus is much higher than in other tissues, probably to protect its endothelial cells against high tension for blood filtration, and may be fulfilled by enriched signaling through the Flk-1 in theglomerulus.

Functional evidence that vascular endothelial growth factor may act as an autocrine factor on human podocytes.

Results indicate that one of the functions of VEGF secreted from podocytes may be to act as an autocrine factor on calcium homeostasis and cell survival.