The role of UNC93B1 protein in surface localization of TLR3 receptor and in cell priming to nucleic acid agonists.

@article{Pohar2013TheRO,
  title={The role of UNC93B1 protein in surface localization of TLR3 receptor and in cell priming to nucleic acid agonists.},
  author={Jelka Pohar and Nina Pirher and Mojca Ben{\vc}ina and Mateja Man{\vc}ek-Keber and Roman Jerala},
  journal={The Journal of biological chemistry},
  year={2013},
  volume={288 1},
  pages={442-54}
}
Translocation of nucleic acid-sensing (NAS) Toll-like receptors (TLRs) to endosomes is essential for response to microbial nucleic acids as well as for prevention of the autoimmune response. The accessory protein UNC93B1 is indispensable for activation of NAS TLRs because it regulates their response through trafficking to endosomes. We observed that poly(I:C) up-regulates transcription of UNC93B1 and promotes trafficking of TLR3 to the plasma membrane in human epithelial cell line. Up… CONTINUE READING