The role of UBL domains in ubiquitin-specific proteases.

  title={The role of UBL domains in ubiquitin-specific proteases.},
  author={Alex C. Faesen and Mark P A Luna-Vargas and Titia Sixma},
  journal={Biochemical Society transactions},
  volume={40 3},
Ubiquitin conjugation and deconjugation provides a powerful signalling system to change the fate of its target enzymes. Ubiquitination levels are organized through a balance between ubiquitinating E1, E2 and E3 enzymes and deubiquitination by DUBs (deubiquitinating enzymes). These enzymes are tightly regulated to control their activity. In the present article, we discuss the different ways in which DUBs of the USP (ubiquitin-specific protease) family are regulated by internal domains with a UBL… CONTINUE READING
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