The role of Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms and CARD15/NOD2 mutations in the susceptibility and phenotype of Crohn's disease.

@article{Brand2005TheRO,
  title={The role of Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms and CARD15/NOD2 mutations in the susceptibility and phenotype of Crohn's disease.},
  author={Stephan Brand and Tanja Staudinger and Fabian Schnitzler and Simone Pfennig and Katrin Hofbauer and Julia Dambacher and Julia Seiderer and Cornelia Tillack and Astrid Konrad and Alexander Crispin and Burkhard J. G{\"o}ke and Peter William Lohse and Thomas Ochsenkuehn},
  journal={Inflammatory bowel diseases},
  year={2005},
  volume={11 7},
  pages={
          645-52
        }
}
BACKGROUND We investigated the influence of 2 common Toll-like receptor 4 (TLR4) polymorphisms on susceptibility and disease characteristics of Crohn's disease (CD). METHODS Genomic DNA from 204 patients with CD and 199 unrelated controls was analyzed for the presence of 2 single nucleotide polymorphisms in the TLR4 gene, resulting in the amino acid substitutions Asp299Gly and Thr399Ile. In addition, the carrier status for the 3 common CD-associated CARD15/NOD2 gene mutations, Arg702Trp… CONTINUE READING
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