The role of Tenascin C in the lymphoid progenitor cell niche.

  title={The role of Tenascin C in the lymphoid progenitor cell niche.},
  author={Sarah L. Ellis and Shen Y. Heazlewood and Brenda M Williams and Andrea J Reitsma and Jochen Grassinger and Judy Borg and Chad K Heazlewood and Ann P. Chidgey and Susan K Nilsson},
  journal={Experimental hematology},
  volume={41 12},
Hemopoietic stem cells (HSCs) are extrinsically controlled by the bone marrow (BM) microenvironment. Mice devoid of the extracellular matrix molecule Tenascin-C (TNC) were reported to develop normally. The current study explores the relationship between TNC and hemopoiesis, from HSCs within their niche to maturing progenitors in alternate niches. Although the absence of TNC did not alter the size of the BM stem cell pool, we report decreased thymic T cell progenitors with redistribution to… CONTINUE READING

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