The role of TXNDC5 in castration-resistant prostate cancer—involvement of androgen receptor signaling pathway

@article{Wang2015TheRO,
  title={The role of TXNDC5 in castration-resistant prostate cancer—involvement of androgen receptor signaling pathway},
  author={Ling Wang and Guizhen Song and Xiaoqing Chang and Wei Tan and Jingbo Pan and Xiaolu Zhu and Zhong Chuan Liu and Meng Qi and Jun Yu and B Han},
  journal={Oncogene},
  year={2015},
  volume={34},
  pages={4735-4745}
}
Castration-resistant prostate cancer (CRPC) continues to be a major clinical problem and the mechanisms behind it remain unclear. Thioredoxin domain-containing protein 5 (TXNDC5) is involved in protein folding and chaperone activity, and its overexpression has been reported in multiple malignancies. In the current study, we demonstrated that TXNDC5 is up-regulated following long-term androgen-deprivation treatment (ADT) and is highly overexpressed in CRPC tumors compared with hormone-naive… CONTINUE READING
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