The role of TRAIL/TRAIL receptors in central nervous system pathology.

@article{Aktas2007TheRO,
  title={The role of TRAIL/TRAIL receptors in central nervous system pathology.},
  author={Orhan Aktas and Ulf Schulze-Topphoff and Frauke Zipp},
  journal={Frontiers in bioscience : a journal and virtual library},
  year={2007},
  volume={12},
  pages={2912-21}
}
Initially, the tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) aroused major interest due to its preferential toxic effect against malignant cells. However, subsequent studies revealed that the TRAIL system, comprising the family of signal-mediating and decoy TRAIL receptors, (i) can also induce death of non-transformed cells, (ii) has… CONTINUE READING