The role of TP53 in Cervical carcinogenesis.

  title={The role of TP53 in Cervical carcinogenesis.},
  author={Massimo Tommasino and Rosita Accardi and Sandra Caldeira and Wen Dong and Ilaria Malanchi and Anouk Smet and Ingeborg Zehbe},
  journal={Human mutation},
  volume={21 3},
Functional loss of the tumor suppressor p53 by alterations in its TP53 gene is a frequent event in cancers of different anatomical regions. Cervical cancer is strongly linked to infection by high-risk human papillomavirus (HPV) types. The viral oncoprotein E6 has the ability to associate with and neutralize the function of p53. E6 interacts with a 100-kDa cellular protein, termed E6 associated protein (E6AP; also called ubiquitin-protein ligase E3A or UBE3A), which functions as an ubiquitin… CONTINUE READING

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