The role of TNF superfamily members in T-cell function and diseases

@article{Croft2009TheRO,
  title={The role of TNF superfamily members in T-cell function and diseases},
  author={Michael Croft},
  journal={Nature Reviews Immunology},
  year={2009},
  volume={9},
  pages={271-285}
}
Interactions that occur between several tumour necrosis factor (TNF)–TNF receptors that are expressed by T cells and various other immune and non-immune cell types are central to T-cell function. In this Review, I discuss the biology of four different ligand–receptor interactions — OX40 ligand and OX40, 4-1BB ligand and 4-1BB, CD70 and CD27, and TL1A and death receptor 3 — and their potential to be exploited for therapeutic benefit. Manipulating these interactions can be effective for treating… CONTINUE READING
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