The role of TNF in cardiovascular disease.

  title={The role of TNF in cardiovascular disease.},
  author={Roberto Ferrari},
  journal={Pharmacological research},
  volume={40 2},
There is increasing evidence that cytokines in general and tumour necrosis factor (TNF) in particular play an important role in cardiovascular disease. This is not surprising since TNF modulates both cardiac contractility and peripheral resistance, the two most important haemodynamic determinants of cardiac function. Thus, increased levels of TNF or of its soluble receptors have been implicated in the pathophysiology of ischaemia-reperfusion injury, myocarditis, cardiac allograft and, more… CONTINUE READING
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