The role of TNF-alpha in insulin resistance.

  title={The role of TNF-alpha in insulin resistance.},
  author={Stephen E. Borst},
  volume={23 2-3},
Insulin resistance is an important component of the metabolic syndrome associated with obesity. Early-stage insulin-resistance and related mild glucose intolerance may be compensated by increased insulin secretion. When combined with impaired insulin secretion, insulin resistance plays an important role in type 2 diabetes (1). Insulin-resistance is also associated with a variety of pathological conditions, including trauma, infection, and cancer. Obesity and type 2 diabetes are the most common… CONTINUE READING


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