The role of TNF-α in regulating ketamine-induced hippocampal neurotoxicity

  title={The role of TNF-α in regulating ketamine-induced hippocampal neurotoxicity},
  author={Xiaozhu Zheng and Jiali Zhou and Yanfei Xia},
  booktitle={Archives of medical science : AMS},
INTRODUCTION Ketamine is commonly used in pediatric anesthesia but recent studies have shown that it could induce neurotoxicity in the developing brain. The inflammatory cytokine, tumor necrosis factor α (TNF-α) is involved in the pathogenesis of various types of neurodegenerations. In the present study, we examined whether TNF-α may regulate ketamine-induced neurotoxicity in the hippocampus of neonatal mouse. MATERIAL AND METHODS The in vitro organotypic culture of hippocampal slices was… CONTINUE READING


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