The role of TGF-beta signaling in myocardial infarction and cardiac remodeling.

@article{Bujak2007TheRO,
  title={The role of TGF-beta signaling in myocardial infarction and cardiac remodeling.},
  author={Marcin Bujak and Nikolaos G Frangogiannis},
  journal={Cardiovascular research},
  year={2007},
  volume={74 2},
  pages={184-95}
}
Transforming Growth Factor (TGF)-beta is markedly induced and rapidly activated in the infarcted myocardium. However, understanding of the exact role of TGF-beta signaling in the infarcted and remodeling heart has been hampered by the complex and unusual biology of TGF-beta activation and by the diversity of its effects eliciting multiple, and often opposing cellular responses. Experimental studies suggest that TGF-beta signaling may be crucial for repression of inflammatory gene synthesis in… CONTINUE READING
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