The role of TGF-beta in epithelial malignancy and its relevance to the pathogenesis of oral cancer (part II).

@article{Prime2004TheRO,
  title={The role of TGF-beta in epithelial malignancy and its relevance to the pathogenesis of oral cancer (part II).},
  author={S. S. Prime and Mark Davies and Miranda Pring and Ian C. Paterson},
  journal={Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists},
  year={2004},
  volume={15 6},
  pages={337-47}
}
The role of transforming growth factor-beta (TGF-beta) in epithelial malignancy is complex, but it is becoming clear that, in the early stages of carcinogenesis, the protein acts as a potent tumor suppressor, while later, TGF-beta can function to advance tumor progression. We review the evidence to show that the pro-oncogenic functions of TGF-beta are associated with (1) a partial loss of response to the ligand, (2) defects of components of the TGF-beta signal transduction pathway, (3) over… CONTINUE READING