The role of TGF-β1–miR-21–ROS pathway in bystander responses induced by irradiated non-small-cell lung cancer cells

@inproceedings{Jiang2014TheRO,
  title={The role of TGF-β1–miR-21–ROS pathway in bystander responses induced by irradiated non-small-cell lung cancer cells},
  author={Yan Jiang and Xiao-fang Chen and Wenqian Tian and Xuemiao Yin and Jie Wang and Huilin Yang},
  booktitle={British Journal of Cancer},
  year={2014}
}
Background:Many studies have indicated an important implication of radiation-induced bystander effects (RIBEs) in cancer radiotherapy, but the detailed signalling remains unclear.Methods:The roles of tumour growth factor-beta1 (TGF-β1) and miR-21 in medium-mediated RIBEs in H1299 non-small-cell lung cancer cells were investigated using DNA damage, changes in proliferation and levels of reactive oxygen species (ROS) as end points. SB431542, a specific inhibitor of TGF-β type 1 receptor kinases… CONTINUE READING
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The adaptive response to X-irradiation in H1299 bystander cells is associated with TGF-b 1 pathway

  • Y Jiang, W Tian, X Yin, J Wang, H Yang
  • J Radiat Res Radiat Process
  • 2014
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