The role of TGF-β in the pathogenesis of primary open-angle glaucoma

  title={The role of TGF-β in the pathogenesis of primary open-angle glaucoma},
  author={Rudolf Fuchshofer and Ernst R Tamm},
  journal={Cell and Tissue Research},
Transforming growth factor-β2 (TGF-β2) is found in increasing amounts in aqueous humor and reactive optic nerve astrocytes of patients with primary open-angle glaucoma (POAG), a major cause of blindness worldwide. The available data strongly indicate that TGF-β2 is a key player contributing to the structural changes in the extracellular matrix (ECM) of the trabecular meshwork and optic nerve head as characteristically seen in POAG. The changes involve an induction in the expression of various… CONTINUE READING
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