The role of TGF-β in patterning and growth of the mammary ductal tree

Abstract

Evidence that transforming growth factor beta (TGF-β)4 influences pattern formation in the developing mammary gland and negatively regulates ductal growth is reviewed. In the mouse, overexpression of TGF-β transgenes during puberty reduces the rate of growth of the ductal tree and simplifies the pattern of arborization, while expression during pregnancy… (More)
DOI: 10.1007/BF02017389

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