The role of TFAM-associated proteins in mitochondrial RNA metabolism.

  title={The role of TFAM-associated proteins in mitochondrial RNA metabolism.},
  author={Takeshi Uchiumi and Dongchon Kang},
  journal={Biochimica et biophysica acta},
  volume={1820 5},
BACKGROUND Mammalian mitochondrial DNA (mtDNA) takes on a higher structure called the nucleoid or mitochromosome, which corresponds to that of nuclear DNA. Mitochondrial transcription factor A (TFAM), which was cloned as a transcription factor for mitochondrial DNA, is critical for forming this higher structure and for maintenance of mtDNA. SCOPE OF REVIEW To investigate the functional aspects of the nucleoid, we have identified many RNA-binding proteins to be candidate TFAM interactors… CONTINUE READING
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