The role of Staphylococcus aureus sortase A and sortase B in murine arthritis.

@article{Jonsson2003TheRO,
  title={The role of Staphylococcus aureus sortase A and sortase B in murine arthritis.},
  author={Ing-Marie Jonsson and S K Mazmanian and Olaf Schneewind and Tomas Bremell and Andrzej Tarkowski},
  journal={Microbes and infection},
  year={2003},
  volume={5 9},
  pages={775-80}
}
Gram-positive pathogenic bacteria display proteins on their surface that play important roles during infection. In Staphylococcus aureus, these surface proteins are anchored to the cell wall by two sortase enzymes, SrtA and SrtB, that recognize specific surface protein sorting signals. The role of sortase enzymes in bacterial virulence was examined using a murine septic arthritis model. Intravenous inoculation with any of the Delta(srtA), Delta(srtB) or Delta(srtAB) mutants resulted in… CONTINUE READING