The role of Smad signaling in hematopoiesis and translational hematology

Abstract

Hematopoietic stem cells (HSCs) reside in the bone marrow (BM) of adult individuals and function to produce and regenerate the entire blood and immune system over the course of an individual's lifetime. Historically, HSCs are among the most thoroughly characterized tissue-specific stem cells. Despite this, the regulation of fate options, such as self… (More)
DOI: 10.1038/leu.2011.95

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