The role of STAT3 and AhR in the differentiation of CD4+ T cells into Th17 and Treg cells

@inproceedings{Liu2017TheRO,
  title={The role of STAT3 and AhR in the differentiation of CD4+ T cells into Th17 and Treg cells},
  author={Xingxing Liu and Hui Hu and Heng Fan and Dongmei Zuo and Zhexing Shou and Y. J. Liao and Zhen Nan and Qing Ying Tang},
  booktitle={Medicine},
  year={2017}
}
BACKGROUND This study aimed to investigate the role of aryl hydrocarbon receptor (AhR) and STAT3 gene during the differentiation of cluster of differentiation (CD)4 T cells into T helper (Th)17 and T regulatory (Treg) cells. METHODS First, CD4 T cells were isolated from the spleen of BALB/c mice. Then, stable CD4 T cells expressing STAT3 shRNA were constructed. CD4 T cells were assigned to one of the following treatments: Th17 group: antibodies against CD3 and CD28, 2.5 ng/mL transforming… CONTINUE READING