The role of SRY-related HMG box transcription factor 4 (SOX4) in tumorigenesis and metastasis: friend or foe?

@article{Vervoort2013TheRO,
  title={The role of SRY-related HMG box transcription factor 4 (SOX4) in tumorigenesis and metastasis: friend or foe?},
  author={Stephin J Vervoort and Ruben van Boxtel and Paul James Coffer},
  journal={Oncogene},
  year={2013},
  volume={32},
  pages={3397-3409}
}
Development and progression of cancer are mediated by alterations in transcriptional networks, resulting in a disturbed balance between the activity of oncogenes and tumor suppressor genes. Transcription factors have the capacity to regulate global transcriptional profiles, and are consequently often found to be deregulated in their expression and function during tumorigenesis. Sex-determining region Y-related high-mobility-group box transcription factor 4 (SOX4) is a member of the group C… CONTINUE READING

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