The role of Rad51 in safeguarding mitochondrial activity during the meiotic cell cycle in mammalian oocytes

Abstract

Rad51 is a conserved eukaryotic protein that mediates the homologous recombination repair of DNA double-strand breaks that occur during mitosis and meiosis. In addition, Rad51 promotes mitochondrial DNA synthesis when replication stress is increased. Rad51 also regulates cell cycle progression by preserving the G2/M transition in embryonic stem cells. In… (More)
DOI: 10.1038/srep34110

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