The role of REST and HDAC2 in epigenetic dysregulation of Nav1.5 and nNav1.5 expression in breast cancer

@article{Kamarulzaman2017TheRO,
  title={The role of REST and HDAC2 in epigenetic dysregulation of Nav1.5 and nNav1.5 expression in breast cancer},
  author={Nur Sabrina Kamarulzaman and Hemaniswarri Dewi Dewadas and Chiuan Yee Leow and Nik Soriani Yaacob and Noor Fatmawati Mokhtar},
  journal={Cancer Cell International},
  year={2017},
  volume={17}
}
  • Nur Sabrina Kamarulzaman, Hemaniswarri Dewi Dewadas, +2 authors Noor Fatmawati Mokhtar
  • Published 2017
  • Medicine, Biology
  • Cancer Cell International
  • BackgroundIncreased expression of voltage-gated sodium channels (VGSCs) have been implicated with strong metastatic potential of human breast cancer in vitro and in vivo where the main culprits are cardiac isoform Nav1.5 and its ‘neonatal’ splice variant, nNav1.5. Several factors have been associated with Nav1.5 and nNav1.5 gain of expression in breast cancer mainly hormones, and growth factors.AimThis study aimed to investigate the role of epigenetics via transcription repressor, repressor… CONTINUE READING

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