The role of Pax-6 in lens regeneration.

  title={The role of Pax-6 in lens regeneration.},
  author={Mayur C Madhavan and Tracy L Haynes and Nicholas C Frisch and Mindy K. Call and Craig M Minich and Panagiotis A. Tsonis and Katia Del Rio-Tsonis},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={103 40},
Pax-6 is a master regulator of eye development and is expressed in the dorsal and ventral iris during newt lens regeneration. We show that expression of Pax-6 during newt lens regeneration coincides with cell proliferation. By knocking down expression of Pax-6 via treatment with morpholinos, we found that proliferation of iris pigment epithelial cells was dramatically reduced both in vitro and in vivo, and, as a result, lens regeneration was significantly retarded. However, induction of… CONTINUE READING