The role of PI3K in immune cells

@article{Koyasu2003TheRO,
  title={The role of PI3K in immune cells},
  author={Shigeo Koyasu},
  journal={Nature Immunology},
  year={2003},
  volume={4},
  pages={313-319}
}
  • S. Koyasu
  • Published 1 April 2003
  • Biology
  • Nature Immunology
Members of the phosphoinositide-3 kinase (PI3K) family control several cellular responses including cell growth, survival, cytoskeletal remodeling and the trafficking of intracellular organelles in many different types of cell. In particular PI3K has important functions in the immune system. It has been difficult to evaluate the roles of distinct PI3Ks in cellular immune responses because no PI3K inhibitors are specific for individual family members and because most stimuli activate several… 
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