The role of PI3K/AKT-related PIP5K1α and the discovery of its selective inhibitor for treatment of advanced prostate cancer.

@article{Semenas2014TheRO,
  title={The role of PI3K/AKT-related PIP5K1α and the discovery of its selective inhibitor for treatment of advanced prostate cancer.},
  author={Julius Semenas and Andreas Hedblom and Regina R. Miftakhova and Martuza Sarwar and Rikard Larsson and Liliya Shcherbina and Martin E Johansson and Pirkko L. H{\"a}rk{\"o}nen and O lov Sterner and Jenny Liao Persson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 35},
  pages={E3689-98}
}
Nitrogen-containing heterocyclic compounds are an important class of molecules that are commonly used for the synthesis of candidate drugs. Phosphatidylinositol-4-phosphate 5-kinase-α (PIP5Kα) is a lipid kinase, similar to PI3K. However, the role of PIP5K1α in oncogenic processes and the development of inhibitors that selectively target PIP5K1α have not been reported. In the present study we report that overexpression of PIP5K1α is associated with poor prognosis in prostate cancer and… CONTINUE READING
11 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 11 extracted citations

Similar Papers

Loading similar papers…