The role of PI3K/AKT, MAPK/ERK and NFkappabeta signalling in the maintenance of human embryonic stem cell pluripotency and viability highlighted by transcriptional profiling and functional analysis.

@article{Armstrong2006TheRO,
  title={The role of PI3K/AKT, MAPK/ERK and NFkappabeta signalling in the maintenance of human embryonic stem cell pluripotency and viability highlighted by transcriptional profiling and functional analysis.},
  author={Lyle Armstrong and Owen Hughes and Sun Yung and Louise Ann Hyslop and Rebecca Marie Stewart and Ilka Wappler and H. -U. Peters and Theresia Walter and Petra Stojkovic and Jerome Evans and Miodrag Stojkovi{\'c} and Majlinda Lako},
  journal={Human molecular genetics},
  year={2006},
  volume={15 11},
  pages={1894-913}
}
Understanding the molecular mechanism by which pluripotency is maintained in human embryonic stem cells (hESC) is important for the development of improved methods to derive, culture and differentiate these into cells of potential therapeutic use. Large-scale transcriptional comparison of the hES-NCL1 line derived from a day 8 embryo with H1 line derived… CONTINUE READING