The role of PFA‐100® testing in the investigation and management of haemostatic defects in children and adults

@article{Harrison2005TheRO,
  title={The role of PFA‐100{\textregistered} testing in the investigation and management of haemostatic defects in children and adults},
  author={Paul J. Harrison},
  journal={British Journal of Haematology},
  year={2005},
  volume={130}
}
The PFA‐100® provides a simple global measure of high shear‐dependent platelet function, and as such is not diagnostic or specific to any disorder. Prolonged closure times must be interpreted in conjunction with a full blood count, von Willebrand factor (VWF) screen and other platelet tests. The PFA‐100® may also give false negative results with relatively common platelet defects. If clinical suspicion is high, further detailed platelet function testing and VWF screening are required to exclude… 
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Platelet function analyzer (PFA)‐100® closure time in the evaluation of platelet disorders and platelet function
TLDR
The PFA‐100 closure time should be considered optional in the evaluation of platelet disorders and function, and its use in therapeutic monitoring of Platelet function is currently best restricted to research studies and prospective clinical trials.
Utility of the PFA-100 as a screening test of platelet function: an audit of haemostasis laboratories in Australia and New Zealand
TLDR
An audit of usage among participants of the Royal College of Pathologists of Australasia Quality Assurance Program reports a wide variety of laboratory usage among these users, including numbers of tests performed, sources of requests, testing criteria and follow-up action.
Comparison Between Bleeding Time and PFA-200 to Evaluate Platelet Function Disorder in Children.
TLDR
The performance of the PFA-200 is compared with the BT for the detection of combined platelet and vWF abnormalities and there are practical advantages of P FA-200 over BT.
Current status and future prospects for platelet function testing in the diagnosis of inherited bleeding disorders
  • N. Dovlatova
  • Medicine, Biology
    British journal of haematology
  • 2015
TLDR
The established platelet function tests used for diagnosing inherited platelet abnormalities in adults and children are summarized, the newly developed methodologies as well as unmet challenges and potential areas for further improvement in this field are discussed.
CHAPTER 23 – Clinical Tests of Platelet Function
Evaluation of platelet function in horses undergoing colic surgery using the PFA-100 platelet function analyser.
TLDR
The aim of the present study was to investigate platelet function in a group of horses suffering ascending colon displacement and who underwent surgery and to conclude that the PFA-100 ® can be used to detect platelets function defects in horses.
Evaluation of platelet function using PFA-100® in patients treated with Acetylsalicylic acid and qualified for Trauma and Orthopedic surgery procedures
TLDR
Normal PLT function assessed using PFA-100® is a common phenomenon in patients with long-term ASA treatment and who are qualified for trauma and orthopedic surgery procedures, although in many cases, it seems that inadequate response to ASA is only a laboratory phenomenon.
Platelet function assays in diagnosis: an update
TLDR
The goals of platelet function testing are to provide a rapid and precise diagnosis to every patient bleeding due to a platelet disorder, to assess the individual bleeding risk and potentially to monitor the efficacy of prohemostatic interventions.
Tests of platelet function
  • U. Shah, A. Ma
  • Medicine, Biology
    Current opinion in hematology
  • 2007
TLDR
Platelet function is complex and may be disrupted at any of a number of steps, including adhesion, aggregation, shape change and secretion, as well as the clinical scenarios in which they are likely to be useful.
The Platelet Function Analyzer (PFA-100) as a Screening Tool in Neurosurgery
TLDR
Preoperative screening with the PFA-100 did result in a significant increase in the administration of desmopressin, which could not reduce perioperative bleeding complications or transfusions.
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