The role of PD-1 and PD-L1 in T-cell immune suppression in patients with hematological malignancies

@inproceedings{Shi2013TheRO,
  title={The role of PD-1 and PD-L1 in T-cell immune suppression in patients with hematological malignancies},
  author={Li Ya Shi and Shaohua Chen and Lijian Yang and Yangqiu Li},
  booktitle={Journal of hematology & oncology},
  year={2013}
}
T-cell activation and dysfunction relies on direct and modulated receptors. Based on their functional outcome, co-signaling molecules can be divided as co-stimulators and co-inhibitors, which positively and negatively control the priming, growth, differentiation and functional maturation of a T-cell response. We are beginning to understand the power of co-inhibitors in the context of lymphocyte homeostasis and the pathogenesis of leukemia, which involves several newly described co-inhibitory… CONTINUE READING