The role of PARP activation in glutamate-induced necroptosis in HT-22 cells.

  title={The role of PARP activation in glutamate-induced necroptosis in HT-22 cells.},
  author={Xingshun Xu and Chu Chang Chua and Min Zhang and D. -G. Geng and Chunfeng Liu and Ronald C. Hamdy and Balvin H. L. Chua},
  journal={Brain research},
Oxidative cell death contributes to neuronal cell death in many neurological diseases such as stroke, brain trauma, and Alzheimer's disease. In this study, we explored the involvement of poly(ADP-ribose)-polymerase (PARP) in oxidative stress-induced necroptosis. We showed that PJ34, a potent and specific inhibitor of PARP, can completely inhibit glutamate-induced necroptosis in HT-22 cells. This protective effect was still observed 8h after glutamate exposure followed by PJ34 treatment. These… CONTINUE READING


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