The role of PARP activation in glutamate-induced necroptosis in HT-22 cells.

@article{Xu2010TheRO,
  title={The role of PARP activation in glutamate-induced necroptosis in HT-22 cells.},
  author={Xingshun Xu and Chu Chang Chua and Min Zhang and D. -G. Geng and Chunfeng Liu and Ronald C. Hamdy and Balvin H. L. Chua},
  journal={Brain research},
  year={2010},
  volume={1343},
  pages={206-12}
}
Oxidative cell death contributes to neuronal cell death in many neurological diseases such as stroke, brain trauma, and Alzheimer's disease. In this study, we explored the involvement of poly(ADP-ribose)-polymerase (PARP) in oxidative stress-induced necroptosis. We showed that PJ34, a potent and specific inhibitor of PARP, can completely inhibit glutamate-induced necroptosis in HT-22 cells. This protective effect was still observed 8h after glutamate exposure followed by PJ34 treatment. These… CONTINUE READING

Citations

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References

Publications referenced by this paper.
Showing 1-10 of 27 references

Use of an aqueous soluble tetrazolium / formazan assay for cell growth assays in culture

C. Culmsee, C. Zhu, +5 authors N. Plesnila
Cancer Commun . • 2005
View 15 Excerpts
Highly Influenced

PARP-1 activation in the ERK signaling pathway.

Trends in pharmacological sciences • 2007
View 1 Excerpt

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