The role of P63 in cancer, stem cells and cancer stem cells

  title={The role of P63 in cancer, stem cells and cancer stem cells},
  author={Marta Nekulov{\'a} and Jitka Holcakova and Philip JB Coates and Borivoj Vojtesek},
  journal={Cellular & Molecular Biology Letters},
The transcription factor p63 has important functions in tumorigenesis, epidermal differentiation and stem cell self-renewal. The TP63 gene encodes multiple protein isoforms that have different or even antagonistic roles in these processes. The balance of p63 isoforms, together with the presence or absence of the other p53 family members, p73 and p53, has a striking biological impact. There is increasing evidence that interactions between p53-family members, whether cooperative or antagonistic… CONTINUE READING

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