The role of Nrf2 and MAPK pathways in PFOS-induced oxidative stress in zebrafish embryos.

@article{Shi2010TheRO,
  title={The role of Nrf2 and MAPK pathways in PFOS-induced oxidative stress in zebrafish embryos.},
  author={Xiongjie Shi and Bingsheng Zhou},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2010},
  volume={115 2},
  pages={391-400}
}
Perfluorooctane sulfonate (PFOS) is a persistent organic pollutant and causes oxidative stress, apoptosis, and developmental toxicity in zebrafish embryos. In the present study, we examined nuclear factor erythroid 2-related factor 2 (Nrf2)- and mitogen-activated protein kinases (MAPKs)-mediated oxidative stress pathways in zebrafish embryos upon exposure to PFOS. Four-hour postfertilization (hpf) zebrafish embryos were exposed to 0.2, 0.4, and 1.0 mg/l PFOS until 96 hpf. PFOS enhanced… CONTINUE READING
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  • J. L. Cook
  • Curr . Pharm . Des .
  • 2003
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