The role of Nox-mediated oxidation in the regulation of cytoskeletal dynamics.

@article{Valdivia2015TheRO,
  title={The role of Nox-mediated oxidation in the regulation of cytoskeletal dynamics.},
  author={Alejandra Valdivia and Charity Duran and Alejandra San Mart{\'i}n},
  journal={Current pharmaceutical design},
  year={2015},
  volume={21 41},
  pages={
          6009-22
        }
}
Nox generated ROS, particularly those derived from Nox1, Nox2 and Nox4, have emerged as important regulators of the actin cytoskeleton and cytoskeleton-supported cell functions, such as migration and adhesion. The effects of Nox-derived ROS on cytoskeletal remodeling may be largely attributed to the ability of ROS to directly modify proteins that constitute or are associated with the cytoskeleton. Additionally, Nox-derived ROS may participate in signaling pathways governing cytoskeletal… CONTINUE READING