The role of Notch and Rho GTPase signaling in the control of dendritic development.

  title={The role of Notch and Rho GTPase signaling in the control of dendritic development.},
  author={Lucille Redmond and Anirvan Ghosh},
  journal={Current opinion in neurobiology},
  volume={11 1},
Dendritic patterning exerts a profound influence on neuronal connectivity. Recent studies indicate that mammalian Notch receptors are expressed by postmitotic neurons and that Notch signaling has a considerable influence on dendritic growth and branching. Investigations into the intracellular effectors of dendritic development have revealed that dendritic growth and branching are differentially affected by activation of the Rho-family GTPases, RhoA, Rac1, and Cdc42. These observations suggest… CONTINUE READING

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