The role of Nogo-A in axonal plasticity, regrowth and repair

@article{Pernet2012TheRO,
  title={The role of Nogo-A in axonal plasticity, regrowth and repair},
  author={Vincent Pernet and Martin E. Schwab},
  journal={Cell and Tissue Research},
  year={2012},
  volume={349},
  pages={97-104}
}
Axonal damage leads to permanent deficits in the adult central nervous system (CNS) not only because of the weak intrinsic ability of adult neurons to activate their growth program but importantly also because of the presence of specific growth inhibitors in the CNS tissue and the environment of the damaged axons. The well-studied myelin-derived protein Nogo-A is involved in various cellular and molecular events contributing to the failure of CNS axons to regrow and reconnect after transection… CONTINUE READING

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