The role of Na-Ca exchange current in the cardiac action potential.

  title={The role of Na-Ca exchange current in the cardiac action potential.},
  author={Natacha Janvier and Mark R. Boyett},
  journal={Cardiovascular research},
  volume={32 1},
Since 1981, when Mullins published his provocative book proposing that the Na-Ca exchanger is electrogenic, it has been shown, first by computer simulation by Noble and later by experiment by various investigators, that inward iNaCa triggered by the Ca2+ transient is responsible for the low plateau of the atrial action potential and contributes to the high plateau of the ventricular action potential. Reduction or complete block of inward iNaCa by buffering intracellular Ca2+ with EGTA or BAPTA… CONTINUE READING


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