The role of NPM, p14arf and MDM2 in precursors of bronchial squamous cell carcinoma.

Abstract

Murine double minute clone 2 (MDM2), p14 alternate reading frame (p14arf), and nucleophosmin (NPM) regulate p53 activity. A total of 200 biopsies, including normal bronchial, pre-invasive and invasive tissues, were examined for changes in NPM, p14arf, MDM2 and p53 expression patterns by immunohistochemistry and immunofluorescence with confocal microscopy… (More)
DOI: 10.1183/09031936.00008408

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