The role of NF-kappaB in Hepatitis b virus X protein-mediated upregulation of VEGF and MMPs.

@article{Liu2010TheRO,
  title={The role of NF-kappaB in Hepatitis b virus X protein-mediated upregulation of VEGF and MMPs.},
  author={Li Liu and Hui-fang Liang and Xiaoping Chen and Wan-guang Zhang and Sheng-li Yang and Tao Xu and Li Ren},
  journal={Cancer investigation},
  year={2010},
  volume={28 5},
  pages={443-51}
}
Hepatitis B virus X protein (HBx) promotes hepatocellular carcinoma (HCC) invasion and metastasis by a poorly understood mechanism. This study investigated the role of NF-kappa B in HBx-mediated upregulation of vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs). In a stably expressing HBx cell line, NF-kappa B level was examined by laser scanning confocal microscopy before and after treatment with pyrrolidine dithiocarbamate (PDTC; an NF-kappa B inhibitor). VEGF… CONTINUE READING