The role of NF-kappaB in 6-hydroxydopamine- and TNFalpha-induced apoptosis of PC12 cells.

@article{Tarabin2004TheRO,
  title={The role of NF-kappaB in 6-hydroxydopamine- and TNFalpha-induced apoptosis of PC12 cells.},
  author={Victoria Tarabin and Markus Schwaninger},
  journal={Naunyn-Schmiedeberg's archives of pharmacology},
  year={2004},
  volume={369 6},
  pages={563-9}
}
6-Hydroxydopamine (6-OHDA) is widely used to study the death of catecholaminergic cells related to Parkinson's disease. Oxidative stress and gene transcription are known to mediate the pro-apoptotic effect of 6-OHDA. As redox mechanisms are involved in activation of the transcription factor NF-kappaB, we studied the role of NF-kappaB in 6-OHDA-induced death of PC12 cells. We stably transfected PC12 cells with a doxycycline-regulated expression vector for the NF-kappaB super-repressor… CONTINUE READING

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