The role of NADPH oxidase in chronic intermittent hypoxia-induced pulmonary hypertension in mice.

@article{Nisbet2009TheRO,
  title={The role of NADPH oxidase in chronic intermittent hypoxia-induced pulmonary hypertension in mice.},
  author={Rachel E. Nisbet and A. S. Graves and Dean J. Kleinhenz and Heidi L. Rupnow and Alana L. Reed and Tai-hwang Michael Fan and Patrick O. Mitchell and Roy L. Sutliff and C. Michael Hart},
  journal={American journal of respiratory cell and molecular biology},
  year={2009},
  volume={40 5},
  pages={
          601-9
        }
}
Obstructive sleep apnea, characterized by intermittent periods of hypoxemia, is an independent risk factor for the development of pulmonary hypertension. However, the exact mechanisms of this disorder remain to be defined. Enhanced NADPH oxidase expression and superoxide (O2(-).) generation in the pulmonary vasculature play a critical role in hypoxia-induced pulmonary hypertension. Therefore, the current study explores the hypothesis that chronic intermittent hypoxia (CIH) causes pulmonary… CONTINUE READING

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