The role of N-methyl-D-aspartate receptors in the regulation of physiologically released dopamine.

@article{Wheeler1995TheRO,
  title={The role of N-methyl-D-aspartate receptors in the regulation of physiologically released dopamine.},
  author={Derek Wheeler and Martyn G Boutelle and Marianne Fillenz},
  journal={Neuroscience},
  year={1995},
  volume={65 3},
  pages={767-74}
}
In vivo voltammetry was used to measure changes in ascorbate, which are an index of changes in the release of glutamate, and microdialysis was used to measure changes in dopamine in the striatum of freely moving rats. A 5 min tail pinch produced a rapid rise in striatal ascorbate paralleled by an increase in motor activity and a slower, more prolonged rise in dopamine. Systemic administration of ketamine or dizocilpine maleate, non-competitive antagonists of the N-methyl-D-aspartate glutamate… CONTINUE READING

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