The role of N-linked glycosylation in the protection of human and bovine lactoferrin against tryptic proteolysis.

Abstract

Lactoferrin (LF) is an iron-binding glycoprotein of the innate host defence system. To elucidate the role of N-linked glycosylation in protection of LF against proteolysis, we compared the tryptic susceptibility of human LF (hLF) variants from human milk, expressed in human 293(S) cells or in the milk of transgenic mice and cows. The analysis revealed that… (More)

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@article{Veen2004TheRO, title={The role of N-linked glycosylation in the protection of human and bovine lactoferrin against tryptic proteolysis.}, author={Harrie A van Veen and Marlieke E J Geerts and Patrick H.C. van Berkel and Jan H. Nuijens}, journal={European journal of biochemistry}, year={2004}, volume={271 4}, pages={678-84} }