The role of MuB in selecting transposition targets of bacteriophage Mu

  • Supervisor Makkuni Jayaram Tanya T. Paull Scott W. Stevens Claus O. Wilke
  • Published 2008


Phage Mu transposes promiscuously, employing MuB protein for target capture. MuB forms stable filaments on A/T-rich DNA, and a correlation between preferred MuB binding and Mu integration has been observed. We have investigated the relationship between MuB-binding and Mu insertion into ‘hot’ and ‘cold’ Mu targets within the E. coli genome. Although higher… (More)

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