The role of MYCN in the failure of MYCN amplified neuroblastoma cell lines to G1 arrest after DNA damage.

Abstract

We previously reported that 3 p53 wild type (wt) MYCN amplified (MNA) neuroblastoma cell lines failed to G1 arrest after DNA damage despite induction of p53, p21(WAF1) and MDM2. We hypothesised that this was due to high MYCN expression. p53 responses to DNA damage were examined in an additional 13 p53 wt neuroblastoma cell lines. MNA was significantly… (More)

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@article{Bell2006TheRO, title={The role of MYCN in the failure of MYCN amplified neuroblastoma cell lines to G1 arrest after DNA damage.}, author={Emma Bell and Rakesh Premkumar and Jane Carr and Xiaohong Lu and Penny E. Lovat and Ursula R. Kees and John Lunec and Deborah Anne Tweddle}, journal={Cell cycle}, year={2006}, volume={5 22}, pages={2639-47} }