The role of MMAC1 mutations in early-onset breast cancer: causative in association with Cowden syndrome and excluded in BRCA1-negative cases.

@article{Tsou1997TheRO,
  title={The role of MMAC1 mutations in early-onset breast cancer: causative in association with Cowden syndrome and excluded in BRCA1-negative cases.},
  author={Hui C. Tsou and David H.F. Teng and Xiao Li Ping and Valeria Brancolini and Thaylon Davis and Rong Hu and Xiao Xun Xie and Alexandra C. Gruener and C A Schrager and Angela M. Christiano and Charis Eng and Peter Steck and J{\"u}rg Ott and Sean V. Tavtigian and Monica Peacocke},
  journal={American journal of human genetics},
  year={1997},
  volume={61 5},
  pages={1036-43}
}
Cowden syndrome (CS) is an autosomal dominant disorder associated with the development of hamartomas and benign tumors in a variety of tissues, including the skin, thyroid, breast, endometrium, and brain. It has been suggested that women with CS are at increased risk for breast cancer. A locus for CS was recently defined on chromosome 10 in 12 families, resulting in the identification of the CS critical interval, between the markers D10S215 and D10S541. More recently, affected individuals in… CONTINUE READING

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