The role of MET receptor tyrosine kinase in non-small cell lung cancer and clinical development of targeted anti-MET agents.

@article{Robinson2013TheRO,
  title={The role of MET receptor tyrosine kinase in non-small cell lung cancer and clinical development of targeted anti-MET agents.},
  author={Kyle W Robinson and Alan B. Sandler},
  journal={The oncologist},
  year={2013},
  volume={18 2},
  pages={115-22}
}
A better understanding of the pathophysiology and evolution of non-small cell lung cancer (NSCLC) has identified a number of molecular targets and spurred development of novel targeted therapeutic agents. The MET receptor tyrosine kinase and its ligand hepatocyte growth factor (HGF) are implicated in tumor cell proliferation, migration, invasion, and angiogenesis in a broad spectrum of human cancers, including NSCLC. Amplification of MET has been reported in approximately 5%-22% of lung tumors… CONTINUE READING
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